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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DGKA All Species: 14.85
Human Site: Y22 Identified Species: 29.7
UniProt: P23743 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23743 NP_001336.2 735 82630 Y22 Q L Q K Y M E Y S T K K V S D
Chimpanzee Pan troglodytes XP_001169813 623 69890
Rhesus Macaque Macaca mulatta XP_001112326 735 82508 Y22 Q L Q K Y M E Y S T K K V S D
Dog Lupus familis XP_531626 735 82556 Y22 Q L Q K Y M E Y S T R K V S D
Cat Felis silvestris
Mouse Mus musculus O88673 730 82744 S23 L Q K Y I E Y S T K R V S D V
Rat Rattus norvegicus P51556 727 82180 Y22 Q L Q K Y I D Y S T K S V S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001235516 802 90547 L60 I L N Q T I D L E G F K L F M
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038780 727 81728 D25 I Q L Q Q Y I D Y C S L K V K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q01583 1211 132942 T198 V H P M L T V T P S P L A S G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03603 812 91362 E82 F S K P P I K E R R T S L F E
Sea Urchin Strong. purpuratus XP_001197889 1217 132437 A490 P E Q H W D I A R S P I N Y E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39017 728 79965 D21 W T S K N P I D T V E S R G L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.6 98.9 92.9 N.A. 82.3 82.7 N.A. N.A. 57.2 N.A. 62 N.A. 34.7 N.A. 46.1 35.3
Protein Similarity: 100 84.6 99.3 97 N.A. 88.9 88.9 N.A. N.A. 70 N.A. 74.5 N.A. 44.9 N.A. 62.1 45.1
P-Site Identity: 100 0 100 93.3 N.A. 0 80 N.A. N.A. 13.3 N.A. 0 N.A. 6.6 N.A. 0 6.6
P-Site Similarity: 100 0 100 100 N.A. 20 93.3 N.A. N.A. 40 N.A. 6.6 N.A. 13.3 N.A. 33.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. 22.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 9 0 0 0 0 9 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 17 17 0 0 0 0 0 9 34 % D
% Glu: 0 9 0 0 0 9 25 9 9 0 9 0 0 0 17 % E
% Phe: 9 0 0 0 0 0 0 0 0 0 9 0 0 17 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 9 0 0 0 9 9 % G
% His: 0 9 0 9 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 17 0 0 0 9 25 25 0 0 0 0 9 0 0 0 % I
% Lys: 0 0 17 42 0 0 9 0 0 9 25 34 9 0 9 % K
% Leu: 9 42 9 0 9 0 0 9 0 0 0 17 17 0 9 % L
% Met: 0 0 0 9 0 25 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 9 0 9 0 0 0 0 0 0 0 9 0 0 % N
% Pro: 9 0 9 9 9 9 0 0 9 0 17 0 0 0 0 % P
% Gln: 34 17 42 17 9 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 17 9 17 0 9 0 0 % R
% Ser: 0 9 9 0 0 0 0 9 34 17 9 25 9 42 0 % S
% Thr: 0 9 0 0 9 9 0 9 17 34 9 0 0 0 0 % T
% Val: 9 0 0 0 0 0 9 0 0 9 0 9 34 9 9 % V
% Trp: 9 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 9 34 9 9 34 9 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _